Project example 1: Haemophilia

Project type	Health economic modelling
Indication	Haemophilia
Intervention	Hemostatic bypassing agents
Methods	Bayesian meta-analysis Dose regimen-dependent efficacy framework
Deliverables	Journal article
Publications	Efficacy of recombinant activated factor VII vs. activated prothrombin complex concentrate for patients suffering from haemophilia complicated with inhibitors: a Bayesian meta-regression. Treur MJ, McCracken F, Heeg B, Joshi AV, Botteman MF, De Charro F, Van Hout B. Haemophilia 2009, in press.

In a Bayesian meta-analysis we integrated all published data on the efficacy of two bypassing agents for the treatment of bleedings in haemophilia patients with inhibitors. In addition, we developed a novel dose-regimen dependent efficacy framework to integrate the dose-regimens in a coherent unifying approach. These methods allowed us to make a comparison between the typical treatment regimens of the two agents based on data of over 2,000 bleeds, rather than using only the data of the two existing direct comparative trials based on 96 and 68 bleeds respectively. The results of this project have been reported in a scientific article in Haemophilia.